Interfaces between Microfluidics and Mass Spectrometry

نویسنده

  • SERGIO FREIRE
چکیده

Stress Methods for Three-Dimensional Flows. J Comput Phys 152:423–456 4. Hirt CW, Nichols BD (1981) Volume of Fluid (VOF) Method for the Dynamics of Free Boundaries. J Comput Phys 39:201–225 5. Jamet D, Torres D, Brackbill JU (2002) On the theory and computation of surface tension: The elimination of parasitic currents through energy conservation in the second-gradient method. J Comput Phys 182:262–276 6. Lakehal D, Meier M, Fulgosi M (2002) Interface Tracking Towards the Direct Simulation of Heat and Mass Transfer in Multiphase Flows. Int J Heat and Fluid Flow 23:242–257 7. Zheng XM, Lowengrub J, Anderson A, Cristini V (2005) Adaptive Unstructured Volume Remeshing, II: Application to Twoand Three-dimensional Level-Set Simulations of Multiphase Flow. J Comput Phys 208:626–650 8. Nadim A (1996) A Concise Introduction to Surface Rheology with Application to Dilute Emulsions of Viscous Drops. Chem Eng Comm 148–150:391–407 9. Olsson E, Kreiss G (2005) A Conservative Level Set Method for Two Phase Flow. J Comput Phys 210:225–246 10. Osher S, Fedkiw R (2003) Level Set Methods and Dynamic Implicit Surfaces. Springer, Berlin 11. Scardovelli R, Zaleski S (1999) Direct Numerical Simulation of Free-Surface and Interfacial Flow. Annu Rev Fluid Mech 31:567–603 12. Sethian J (1999) Level Set Method and Fast Marching Methods. Cambridge University Press, Cambridge 13. Sun Y, Beckermann C (2007) Sharp Interface Tracking Using the Phase-Field Equation. J Comput Phys 220:626–653 14. SussmanM, Puckett EC (2000) A Coupled Level Set and Volume of Fluid Method for Computing 3D and Axisymmetric Incompressible Two-Phase Flows. J Comput Phys 162:301–337 15. Unverdi SO, Tryggvason G (1992) A Front-Tracking Method for Viscous, Incompressible, Multi-Fluid Flows. J Comput Phys 100:25–37

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Proteome-on-a-chip: mirage, or on the horizon?

Proteomics has emerged as the next great scientific challenge in the post-genome era. But even the most basic form of proteomics, proteome profiling, i.e., identifying all of the proteins expressed in a given sample, has proven to be a demanding task. The proteome presents unique analytical challenges, including significant molecular diversity, an extremely wide concentration range, and a tende...

متن کامل

On-chip spyhole mass spectrometry for droplet-based microfluidics.

For efficient coupling of droplet-based microfluidics with mass spectrometry (MS), a spyhole drilled on the top of a microchip is used to sample the passing droplets by electrostatic-spray ionization (ESTASI) MS. The technique involves placing an electrode below the chip under the spyhole and applying high-voltage pulses. Electrospray occurs directly from the spyhole, and the droplet content is...

متن کامل

Microfluidics Interfacing to Mass Spectrometry

Title of Document: MICROFLUIDICS INTERFACING TO MASS SPECTROMETRY YI ZHOU, Doctor of Philosophy, 2007 Directed By: Dr. Don L. Devoe, Associate Professor, Department of Mechanical Engineering Polymer-based microfluidic systems have received considerable attention for high throughput chemical analysis. Recently, the ongoing development of microfluidics interfacing to high-accuracy mass spectromet...

متن کامل

Bioaffinity Mass Spectrometry Screening Using Droplet-Based Microfluidics

Bioaffinity mass spectrometry screening is a novel approach using non-denaturing electrospray ionization (ESI) mass spectrometry (MS) in identifying drug leads. This screening technique can detect and preserve noncovalent protein-active drug ligand complexes under different physiological conditions. Although there are many successful screening campaigns employing this technique, the big challen...

متن کامل

Using Microfluidics and Mass Spectrometry to Study Peptide Release in Neurons

We present here two microfluidic devices designed to create and maintain a neuronal network and characterize its response to chemical stimulation using mass spectrometry. The first microfluidic device is composed of microvalve controlled PDMS channels that are adhered to an octadecyltrichlorosilane functionalized silicon wafer. This surface functionalization provides for neuropeptide releasate ...

متن کامل

Microfluidics in biotechnology

Microfluidics enables biotechnological processes to proceed on a scale (microns) at which physical processes such as osmotic movement, electrophoretic-motility and surface interactions become enhanced. At the microscale sample volumes and assay times are reduced, and procedural costs are lowered. The versatility of microfluidic devices allows interfacing with current methods and technologies. M...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2008